 |
|
Mr. Ed, the talking horse of TV fame, very likely would be aghast—and no doubt would have some spry comment to make about the goings-on today in horsedom. Italian scientists have just announced that they have cloned the first horse.
This proclamation trailed by a little more than two months the announcement, on May 30, 2003, of the cloning of the first mule (which joined sheep, goats, pigs, cattle, rabbits, mice, and cats in the list of animals already cloned). Gordon Woods of the University of Idaho (Moscow)—using funding from a mule-racing philanthropist—successfully cloned the mule, which was born on May 4 and named Idaho Gem (see Woods, et al., 2003).
But the mule’s claim to fame is nothing compared to that of the foal (named Prometea, after the Greek god Prometheus who stole fire from the gods and gave it to man) that was born twenty-four days later on May 28. According to Cesare Galli and his research team at the Laboratorio di Technologie della Reproduzione in Cremona, Italy, what makes Prometea so special (aside from the fact that she is the first horse ever to be cloned) is the fact that the mare from which the somatic cells were taken in order to make the clone, also served as the surrogate mother for the cloned embryo. In other words, the mare gestated and gave birth to its twin. Or, as Galli put it: “Basically, she foaled herself ” (as quoted in Weiss, 2003).
But none of this came easily. One science writer lamented: “As has been the case with cloning in other species, the process was inefficient” (Weiss, 2003). That’s putting it mildly. In the case of Prometea, the Italian scientists removed a single somatic (skin) cell from a 6-year-old Haflinger mare, and fused its nucleus with an egg cell (retrieved from an ovary in a horse at an abattoir) whose own genetic material had been removed. [For a history of cloning from 1900 to the present, see our article at: http://www.apologeticspress.org/articles/2512; for a summary of the nuclear somatic cell cloning process, see our article at: http://www.apologeticspress.org/articles/2511.] That newly constituted cell grew in a laboratory Petri dish for eight days before being transferred to the mare (after she had experienced ovulation) for a standard 11-month gestation period.
But while the embryo from which Prometea grew was the only embryo to be carried to term successfully, it hardly was the only embryo involved in the cloning process. In fact, in their report in Nature, Galli, et al., reported that they had painstakingly created 841 embryos, of which all but about two dozen died during their first week in the laboratory environment. The scientists transferred 17 embryos to the wombs of surrogate mother horses, which ultimately resulted in four pregnancies. Two of those ended spontaneously within the first 30 days, and a third aborted after 187 days, all for unknown reasons. [It took over 277 embryos to successfully clone Dolly the sheep. Scientists are reporting success rates of only 1-2%, and of those animals that do live, many become abnormal adolescents and adults.] Such poor results are the norm, not the exception, as the chart below substantiates.
|
Animal |
Number of embryos needed to produce one clone |
|
Cat |
87 |
|
Cattle |
10 |
|
Goat |
112 |
|
Horse |
841 |
|
Human |
??? |
|
Mouse |
942 |
|
Mule |
305 |
|
Pig |
110 |
|
Rabbit |
1084 |
|
Sheep |
277 |
Table 1 — Figures represent results from the first research laboratory that was successful in cloning a particular mammal. [Numbers do not include those embryos from other labs, or the total number of eggs that never reached the blastocyst stage.]
Prometea, who was born at 1:45 a.m. on May 28, weighed 79 pounds (about average for a Haflinger foal). Other scientists have been trying to clone horses as well—but without any success thus far. Robert Godke of Louisiana State University in Baton Rouge admitted: “The horse has been kind of a toughie for us” (as quoted in Pilcher, 2003). In fact, Dr. Godke went on to admit defeat by saying: “I’m a whipped dog” (as quoted in Pearson). According to the Washington Post, some of my former colleagues in the College of Veterinary Medicine at Texas A&M University (where I taught for a number of years) are expecting a second cloned horse to be born in November 2003 (see Weiss, 2003).
What are the ramifications of all of this? Cloning of horses, for a start, would allow geldings (male horses that have been castrated) to “reproduce,” thereby adding their DNA into the equine gene pool for the first time. Then, of course, there is the elusive promise of being able to clone another Seabiscuit or Secretariat—a concept that, apparently, has not been lost on horse breeders and racing associations. As Weiss noted:
The 109-year-old Jockey Club, for example, which manages the official registry for North American thoroughbreds, last year added language to its rules explicitly precluding cloned horses from registering or participating in races. In March, the American Quarter Horse Association adopted similar language.
And so, a horse may not be a horse, of course. As George Orwell pointed out in his satire, Animal Farm, although all animals are created equal, some apparently are created “more equal” than others.
In the end, horse cloning may prove most beneficial, not for racing steeds, but for those everyday animals that are in a sort of “race for survival”—i.e., those endangered breeds whose populations have dwindled to very low numbers but that are too wild to be targeted for artificial insemination or embryo transfer efforts. Time will tell. In the meantime, everyone seems to agree with Ian Wilmut (the Scottish scientist who cloned Dolly) that the cloning of a horse is “a technological achievement” (as quoted in Pilcher). Indeed it is. Now, if they can just get Prometea to talk.
REFERENCES
Galli, Cesare, Irina Laguitina, et al. (2003), “A Cloned Horse Born to Its Dam Twin,” Nature, 424:635, August 7.
Pearson, Helen (2003), “Mule Cloned,” Nature Scienceupdate [On-line], URL: http://www.nature.com/nsu/nsu-pf/030527/030527-9.html, May 30.
Pilcher, Helen R. (2003), “First Cloned Horse Born,” Nature Scienceupdate [On-line], URL: http://www.nature.com/nsu/030804/030804-8.html, August 7.
Weiss, Rick (2003), “First Cloned Horse Created in Italy,” Washington Post [On-line], URL: http://www.washingtonpost.com/wp-dyn/articles/A25717-2003Aug6.html, August 6.
Woods, Gordon L., Kenneth L. White, et al. (2003), “A Mule Cloned from Fetal Cells by Nuclear Transfer,” Sciencexpress, [On-line], URL: http://www.sciencemag.org/cgi/doi/10.1126/science.1086743, May 30.
Copyright © 2003 Apologetics Press, Inc. All rights reserved.
We are happy to grant permission for items in the "In the News" section to be reproduced in their entirety, as long as the following stipulations are observed: (1) Apologetics Press must be designated as the original publisher; (2) the specific Apologetics Press Web site URL must be noted; (3) the authors name must remain attached to the materials; (4) any references, footnotes, or endnotes that accompany the article must be included with any written reproduction of the article; (5) alterations of any kind are strictly forbidden (e.g., photographs, charts, graphics, quotations, etc. must be reproduced exactly as they appear in the original); (6) serialization of written material (e.g., running an article in several parts) is permitted, as long as the whole of the material is made available, without editing, in a reasonable length of time; (7) articles, in whole or in part, may not be offered for sale or included in items offered for sale; and (8) articles may be reproduced in electronic form for posting on Web sites pending they are not edited or altered from their original content and that credit is given to Apologetics Press, including the web location from which the articles were taken.
For catalog, samples, or further information, contact:
Apologetics Press
230 Landmark Drive
Montgomery, Alabama 36117
U.S.A.
Phone (334) 272-8558
http://www.apologeticspress.org
|  |